PTSW-0 suppository dissolution test cell for drug release testing from hydrophobic carrier preparations
The PTSW-0 Suppository Dissolution Test Cell (Rotating Dialysis Cell) is placed into a normal USP type dissolution vessel placed into a dissolution bath to test the rate of dissolved active of suppositories and lipophilic carriers.
PTSW-0 Suppository Dissolution Tester
Construction
The cell is emerged in the dissolution vessel. It is developed for the study of drug release from hydrophobic carrier preparations, such as suppositories. It encloses a small volume (max. 30ml) of inner fluid by means of a dialysis membrane. The cell itself rotates horizontally in a larger volume of test media which has the same pH as the inner volume. The sample is inside the inner cell. The rotating speed is reduced in a rotation of 2:1. The active dissolves through the membrane into the outer phase and can be measured therein using common technology like UV/VIS. It is proved that the cell is a suitable tool to study factors which may influence the dissolution and absorption of controlled release formulations.
Cell Design
| Parameter | Specification |
| Cell rotation speed | 5 - 60 rpm |
| Drive gear | Speed reduction ratio 2.1 |
| Filter membrane | Typical: Millipore Durapor HPVL 0.45 µm |
We reserve the right to make technical changes without any prior notice.
