PTWS 1420

The new 14+2 station dissolution testing instrument – ideal for comparative studies such as biowaiver tests.

PTWS 1420

The new 14+2 station dissolution testing instrument – ideal for comparative studies such as biowaiver tests.

The PTWS 1420 is a 14+2-position, "dual drive" compact tablet dissolution testing instrument for solid dosage forms as described in USP chapter [711/724] and EP section[2.9.3/4] as well as the BP, DAB and Japanese Pharmacopeia section [15]. The instrument features 14 testing positions and includes two additional standard size vessels for media refilling and reference standard media. PTWS 1420 features independent stirrer speed control for the left and right half of stirrers.

Auto Vessel Centering System
The PTWS 1420 features a new auto vessel centering system using a plastic ring which serves to both hold and center the dissolution vessel. The access points for sampling as well as the openings for the tools are contained in an auxiliary, low evaporation, vessel cover. Each USP Borosilicate glass vessel has a unique batch code on top of the flange for easy visibility and positioned placement inside the water bath cover.

PTWS 1420 in raised position

Lift Mechanism
The upper drive is motorized and electronically controlled it offers eight programmable positions: an upper cleaning and instrument qualification position and lower working positions are programmable depending on the type of stirring tool used. The upper position offers ideal access to the stirring tools and vessels for a change of tools and cleaning steps between the dissolution tests. The motorized drive head lifting mechanism is positioned in a way so that the tool shafts are always kept parallel and at a 90° angle to the vessel walls when in the working position.

Automation Capabilities
The motorized EPE-1420 sampling system lowers the sampling probes into the media and after sampling raises them back out again. 8 different sampling positions can be programmed. The ITM-1420 individual media temperature monitoring system is attached to the EPE-1420 and will read and report the vessel media temperatures in all 14 vessels while sampling. The motorized TMA-1420 tablet dropping magazine completes the set of useful accessories for automation. The magazine insures the simultaneous drop of up to 14 samples. It covers all vessels and ensures low evaporation rates during the dissolution test. The magazines include magnetic holders for the tube cleaning device.

Space Requirements
A key point in today’s crowded labs is the footprint of the PTWS 1420 compared to two conventional dissolution baths. With less than 100cm of total width for the main instrument, PTWS 1420 features a sturdy design and yet makes optimal use of the limited space available in a typical laboratory.

  • Fully USP [711/724] and EP [2.9.3/4] compliant
  • 14 stirred vessel positions, 2 additional heated vessels for replacement media
  • Dual drive configuration with two stirrer motors
  • CAN Bus technology offering instrument suitability check prior to start of a test run
  • Staggered start capability
  • Vessel low evaporation sealing covers
  • Removable water bath for easy cleaning
  • Drainage tap to empty the bath
  • Method management and user administration
  • User access control
  • Optical and acoustic signals to inform about sampling intervals,
  • Timer count down function
  • Traffic Light optical information on display shows the instrument status by different colors (green = ready to use, yellow = preparing to use, red = error encountered)
  • OQ, PQ interval warning with programmable interval
  • Interfaces: USB port for remote control of the PTWS 1420, RS232 port to connect serial devices, I/O port for remote control of external instruments in automated applications, like DSR-M, pumps
  • Calibration menu for stirrer speed, bath temperature and moreand PTFC-16

  • 14 stirred vessel in one instrument is ideal for Biowaiver applications and offline automated systems
  • Dual drive configuration with independent speed control for left and right side of instrument enables flexible use of the PTWS 1420
  • Replacement media is stored in two additional heated vessels eliminating influences from cold media refilling
  • Easy to use auto vessel centering system
  • Eco friendly double walled vacuum molded water bath for improved temperature insulation
  • Screen saver functionality offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
  • Wake up functionality to start heating at a pre-programmed time
  • Programmable infinity test
  • MonoShaft™ system to avoid re-adjustment of immersion depth after tool exchange
  • Staggered start feature for convenient manual sampling
  • Water diffuser for even temperature distribution
  • IQ/OQ documents included free of charge

Technical Specifications

Parameter Specification
Display 6″, 320×240 pixel color LCD, illuminated
Data Entry Resistive touch screen, functional touch keys
Acoustic Signal Programmable acoustic signal for operator information
Timer Programmable sampling times, wake-up and sleeping mode, operation time information and timer count-down mode
Stirrer Position 8 programmable stirrer immersion positions (paddle over disk, transdermal cylinder etc.)
Testing Method Programming Unlimited number of different test descriptions can be stored on SD card
User Access Control Multiple level access control, CFR compliant
OQ, PQ control Programmable time periods to remind on QO or PQ testing
Printer External PT-RP80 report printer using long-life printer paper
Number of Stirred Vessels 14 vessels in a 2x 6+1 arrangement
Number of Additional Vessels 2 unstirred and heated vessels to store replacement medium
Standard Vessels 1 liter USP/EP Borosilicate glass vessel, each individually coded
Vessel Covers Ultra-low evaporation design (< 0.7% within 24h)
Stirring Speed Control 25 – 250 RPM
Speed Accuracy ±2% of set speed, typically < 1%
Stirrer Shaft Wobble Better than 0.2 mm total run out
System Tools MonoShaft™ stirrer design, USP/EP apparatus 1, 2, 5, 6 tool adapter, cream cell, transdermal patch tools, each tool and vessel individually coded
Heating System Pump for water circulation and 1500W heater for fast heating up (230/240V units only)
Heater Range 25 - 45°C
Heater Accuracy ± 0.2°C inside the water bath
Heat Up Process Energy saving, programmable “wake up” heater function and “sleep mode”
Water Circulation Water circulated from external heating system through special diffuser inside the water bath
Vibration Elimination External heating system, spring loaded pump assembly
Calibration Built-in calibration procedures for speed, temperature control, OQ/PQ interval programmable including alarm indicator
Instrument Dimensions Bath: approx. 97cm x 69cm x 82cm (width x depth x height)
Heater: approx. 26cm x 37cm x 21cm (width x depth x height)
Net Weight Approx. 105 kg
Certification All components certified to USP / EP requirements
CE / EMC Certification All CE / EMC Certification provided
Validation All IQ & OQ documents included

We reserve the right to make technical changes without any prior notice.

Included in the Standard Supply Scope
  • One set of 14 stainless steel paddles
  • One set of 16 batch coded 1000ml Borosilicate glass vessels
  • One set of depth adjustment balls
  • One bottle of ALGEX water preservative
  • Comprehensive documentation folder including:
    • User manual
    • DQ/QC instrument compliance test certificate
    • IQ documentation
    • OQ documentation
    • Instrument logbook
    • Compliance certificates for vessels and stirring tools


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